{"id":78,"date":"2023-12-19T12:10:43","date_gmt":"2023-12-19T12:10:43","guid":{"rendered":"http:\/\/www.igclinic.ie\/?page_id=78"},"modified":"2023-12-19T12:10:43","modified_gmt":"2023-12-19T12:10:43","slug":"cleft-lip-and-palate","status":"publish","type":"page","link":"http:\/\/www.igclinic.ie\/?page_id=78","title":{"rendered":"Cleft Lip and Palate"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Cleft lip (CL) and palate (CP) occurs as part of many other mal-formation syndromes in a non-specific manner more frequently than would be expected. The aetiology of isolated clefts, without syndromic features or family history, however, is likely a result of genetic and environmental factors.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">The population incidence is:<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>1 in 500 \u2013 1 in 1000 for cleft lip (with or without cleft palate). It is unilateral in 80% of cases with the left side more commonly affected. Males are often ore severe.<\/li>\n\n\n\n<li>1 in 2500 for isolated cleft palate. The spectrum of abnormalities ranges from bifid uvula to submucous cleft to velopharyngeal insufficiency (regurgitation f milk in children to nasal speech in adults).<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\">Prevents Re-occurrence<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Recent case control studies have shown that periconceptual folate supplementation has a 47% risk reduction in CL\/P in offspring of when compared to no maternal folate supplementation.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>A dose of 5mg\/day is recommended for women with a previous occurrence and 400mcg\/day where there is no prior history.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Cleft lip (CL) and palate (CP) occurs as part of many other mal-formation syndromes in a non-specific manner more frequently than would be expected. The aetiology of isolated clefts, without syndromic features or family history, however, is likely a result of genetic and environmental factors. The population incidence is: Prevents Re-occurrence Recent case control studies [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-78","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"http:\/\/www.igclinic.ie\/index.php?rest_route=\/wp\/v2\/pages\/78","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.igclinic.ie\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/www.igclinic.ie\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/www.igclinic.ie\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.igclinic.ie\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=78"}],"version-history":[{"count":1,"href":"http:\/\/www.igclinic.ie\/index.php?rest_route=\/wp\/v2\/pages\/78\/revisions"}],"predecessor-version":[{"id":79,"href":"http:\/\/www.igclinic.ie\/index.php?rest_route=\/wp\/v2\/pages\/78\/revisions\/79"}],"wp:attachment":[{"href":"http:\/\/www.igclinic.ie\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=78"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}