{"id":84,"date":"2023-12-19T12:12:56","date_gmt":"2023-12-19T12:12:56","guid":{"rendered":"http:\/\/www.igclinic.ie\/?page_id=84"},"modified":"2024-01-19T14:16:39","modified_gmt":"2024-01-19T14:16:39","slug":"ehlers-danlos-syndrome","status":"publish","type":"page","link":"http:\/\/www.igclinic.ie\/?page_id=84","title":{"rendered":"Ehlers Danlos Syndrome"},"content":{"rendered":"\n<p class=\"has-large-font-size wp-block-paragraph\">Ehlers Danlos Syndrome<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Ehlers Danlos Syndrome (EDS) is subdivided into several subtypes (types I-VIII) with different inheritance patterns and collagen gene mutations.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The most common and\/ or significant EDS types (I-IV and VI) are described below.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Epidemiology<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Prevalence ~1\/5000<\/li>\n\n\n\n<li>EDS type III (hypermobility) is the most common and is usually mild<\/li>\n\n\n\n<li>EDS type IV is uncommon but is a serious disorder<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Clinical presentation<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Patients may present with:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Skin: fragility, easy bruising, thin atrophic scars<\/li>\n\n\n\n<li>Joints: hypermobility, premature osteoarthritis.<\/li>\n\n\n\n<li>Intestinal perforation; bladder, uterine and arterial rupture (type IV)<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Physical Signs<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Classical EDS (types I, II)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Skin: soft, thin atrophic scars, bruising<\/li>\n\n\n\n<li>Joints: hyperextensible<\/li>\n\n\n\n<li>Varicose veins<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Hypermobility (type III)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Skin: soft<\/li>\n\n\n\n<li>Joints: hyperextensible, recurrent dislocations<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Vascular (type IV)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Subcutaneous fat loss<\/li>\n\n\n\n<li>Pinched nose<\/li>\n\n\n\n<li>Thin lips<\/li>\n\n\n\n<li>Hollowed cheeks<\/li>\n\n\n\n<li>Skin thin and translucent, veins often visible<\/li>\n\n\n\n<li>Limited large joint hyperextensibility<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Kyphoscoliosis (type VI)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Skin: soft and hyperextensible<\/li>\n\n\n\n<li>Joints: hypermobile<\/li>\n\n\n\n<li>Muscle hypotonia<\/li>\n\n\n\n<li>Scoliosis<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Complications<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Aortic root dilatation (Types I, II 33%; type III 20%)<\/li>\n\n\n\n<li>Premature osteoarthritis<\/li>\n\n\n\n<li>Premature labour, post-partum haemorrhage (types I, II)<\/li>\n\n\n\n<li>Optic globe rupture (type VI)<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">EDS type IV<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Uterine, bowel and arterial rupture<\/li>\n\n\n\n<li>Complications occur in at least 25% of individuals after 20 years of age and 80% before 40 years of age.<\/li>\n\n\n\n<li>Arterial repair not always technically possible.<\/li>\n\n\n\n<li>Shortened life expectancy, median 48 years.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Ehlers Danlos Syndrome Ehlers Danlos Syndrome (EDS) is subdivided into several subtypes (types I-VIII) with different inheritance patterns and collagen gene mutations. The most common and\/ or significant EDS types (I-IV and VI) are described below. Epidemiology Clinical presentation Patients may present with: Physical Signs Classical EDS (types I, II) Hypermobility (type III) Vascular (type [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-84","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"http:\/\/www.igclinic.ie\/index.php?rest_route=\/wp\/v2\/pages\/84","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.igclinic.ie\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/www.igclinic.ie\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/www.igclinic.ie\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.igclinic.ie\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=84"}],"version-history":[{"count":2,"href":"http:\/\/www.igclinic.ie\/index.php?rest_route=\/wp\/v2\/pages\/84\/revisions"}],"predecessor-version":[{"id":375,"href":"http:\/\/www.igclinic.ie\/index.php?rest_route=\/wp\/v2\/pages\/84\/revisions\/375"}],"wp:attachment":[{"href":"http:\/\/www.igclinic.ie\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=84"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}