{"id":98,"date":"2023-12-19T12:15:51","date_gmt":"2023-12-19T12:15:51","guid":{"rendered":"http:\/\/www.igclinic.ie\/?page_id=98"},"modified":"2023-12-19T12:15:51","modified_gmt":"2023-12-19T12:15:51","slug":"prader-willi-syndrome","status":"publish","type":"page","link":"http:\/\/www.igclinic.ie\/?page_id=98","title":{"rendered":"Prader-Willi Syndrome"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Prader-Willi syndrome (PWS) is the most recognised form of inherited childhood obesity.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Epidemiology<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Incidence: 1 in 10 000-15 000<\/li>\n\n\n\n<li>All ethnic groups<\/li>\n\n\n\n<li>Male = Female<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Clinical Presentation<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Clinical features are variable<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Breech presentation in utero<\/li>\n\n\n\n<li>Feeding problems in infancy<\/li>\n\n\n\n<li>Failure to thrive initially<\/li>\n\n\n\n<li>Hyperphagia<\/li>\n\n\n\n<li>Truncal obesity<\/li>\n\n\n\n<li>Morbid obesity developing between ages 1-6 years<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Physical Signs<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Almond-shaped palpebral fissures<\/li>\n\n\n\n<li>Down-turned corners of the mouth<\/li>\n\n\n\n<li>Small hands and feet<\/li>\n\n\n\n<li>Hypotonia<\/li>\n\n\n\n<li>Microcephaly<\/li>\n\n\n\n<li>Hypogonadotrophic hypogonadism (males and females)<\/li>\n\n\n\n<li>Mental disability (IQ evenly distributed around 60 mark).<\/li>\n\n\n\n<li>Short&nbsp; stature<\/li>\n\n\n\n<li>Dental malocclusion (40%)<\/li>\n\n\n\n<li>Cryptorchidism (80%)<\/li>\n\n\n\n<li>Labial hypoplasia<\/li>\n\n\n\n<li>Micropenis<\/li>\n\n\n\n<li>Strabismus (40-95%)<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Complications<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Fertility is rare in men and un-common in women.<\/li>\n\n\n\n<li>Day time sleepiness is common (50-90%)<\/li>\n\n\n\n<li>Respiratory problems and sleep apnoea requiring anaesthetic precautions<\/li>\n\n\n\n<li>Congestive heart failure due to morbid obesity<\/li>\n\n\n\n<li>Diabetes mellitus (15%)<\/li>\n\n\n\n<li>Older children and adults are often depressed<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Prader-Willi syndrome (PWS) is the most recognised form of inherited childhood obesity. Epidemiology Clinical Presentation Clinical features are variable Physical Signs Complications<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-98","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"http:\/\/www.igclinic.ie\/index.php?rest_route=\/wp\/v2\/pages\/98","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.igclinic.ie\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/www.igclinic.ie\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/www.igclinic.ie\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.igclinic.ie\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=98"}],"version-history":[{"count":1,"href":"http:\/\/www.igclinic.ie\/index.php?rest_route=\/wp\/v2\/pages\/98\/revisions"}],"predecessor-version":[{"id":99,"href":"http:\/\/www.igclinic.ie\/index.php?rest_route=\/wp\/v2\/pages\/98\/revisions\/99"}],"wp:attachment":[{"href":"http:\/\/www.igclinic.ie\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=98"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}