{"id":88,"date":"2023-12-19T12:13:54","date_gmt":"2023-12-19T12:13:54","guid":{"rendered":"http:\/\/www.igclinic.ie\/?page_id=88"},"modified":"2023-12-19T12:13:54","modified_gmt":"2023-12-19T12:13:54","slug":"fragile-x-syndrome","status":"publish","type":"page","link":"https:\/\/www.igclinic.ie\/?page_id=88","title":{"rendered":"Fragile X Syndrome"},"content":{"rendered":"\n<p>Fragile X is the commonest form of in-herited learning disorder in males.<\/p>\n\n\n\n<p><strong>Epidemiology<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Prevalence 1 in 5,700 in males with a full FRAXA mutation<\/li>\n\n\n\n<li>Males affected<\/li>\n\n\n\n<li>Females are usually unaffected carriers.<\/li>\n\n\n\n<li>Some individuals carry smaller expansions.<\/li>\n<\/ul>\n\n\n\n<p><strong>Clinical presentation<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Full mutations in males<\/li>\n\n\n\n<li>Intelligence quotient is significantly reduced in males to approximately 41.<\/li>\n\n\n\n<li>Developmental delay with hypotonia is common<\/li>\n\n\n\n<li>Speech and language varies from no speech to mild . Individual rarely can speak fluently.<\/li>\n\n\n\n<li>Behaviour is characterised by overactivity, impulsiveness, reduced concentration and poor social interaction often punctuated by aggression. Autistic spectrum features are common.<\/li>\n\n\n\n<li>Many children have some degree of minor joint laxity.<\/li>\n\n\n\n<li>Macrocephaly<\/li>\n\n\n\n<li>Macro-orchidism<\/li>\n\n\n\n<li>Large ears<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Fragile X is the commonest form of in-herited learning disorder in males. Epidemiology Clinical presentation<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-88","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.igclinic.ie\/index.php?rest_route=\/wp\/v2\/pages\/88","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.igclinic.ie\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.igclinic.ie\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.igclinic.ie\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.igclinic.ie\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=88"}],"version-history":[{"count":1,"href":"https:\/\/www.igclinic.ie\/index.php?rest_route=\/wp\/v2\/pages\/88\/revisions"}],"predecessor-version":[{"id":89,"href":"https:\/\/www.igclinic.ie\/index.php?rest_route=\/wp\/v2\/pages\/88\/revisions\/89"}],"wp:attachment":[{"href":"https:\/\/www.igclinic.ie\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=88"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}